UBE2J2 (ubiquitin conjugating enzyme E2 J2)

2014-08-01  

Identity

HGNC
UBE2J2
LOCATION
1p36.33
LOCUSID
118424
ALIAS
NCUBE-2,NCUBE2,PRO2121
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 118424
HGNC: 19268
Ensembl: ENSG00000160087

Variants:

dbSNP: 118424
ClinVar: 118424
TCGA: ENSG00000160087
COSMIC: UBE2J2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160087ENST00000347370A6NGS0
ENSG00000160087ENST00000349431Q8N2K1
ENSG00000160087ENST00000349431A0A024R075
ENSG00000160087ENST00000360466Q8N2K1
ENSG00000160087ENST00000360466A0A024R075
ENSG00000160087ENST00000400929A6NGS0
ENSG00000160087ENST00000400930Q8N2K1
ENSG00000160087ENST00000422076B1AMF1
ENSG00000160087ENST00000435198B1AMF0
ENSG00000160087ENST00000450390D6REN4
ENSG00000160087ENST00000464036D6RC43
ENSG00000160087ENST00000466752D6R9H0
ENSG00000160087ENST00000473215D6R9H0
ENSG00000160087ENST00000477894D6RA15
ENSG00000160087ENST00000488418D6REN4
ENSG00000160087ENST00000502382D6RB84
ENSG00000160087ENST00000503294D6R9H0
ENSG00000160087ENST00000509720D6RD90

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
306581892019Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.9
306581892019Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.9
287437402017Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.11
287437402017Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.11
250838002014The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation.7
250838002014The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation.7
200613862010The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.79
200613862010The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.79

Citation

Dessen P

UBE2J2 (ubiquitin conjugating enzyme E2 J2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54744/ube2j2-(ubiquitin-conjugating-enzyme-e2-j2)