Identity
HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
C6orf133,bA49A4.1,dJ242G1.1,dJ392M17.3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23304
MIM: 609134
HGNC: 21289
Ensembl: ENSG00000024048
Variants:
dbSNP: 23304
ClinVar: 23304
TCGA: ENSG00000024048
COSMIC: UBR2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000024048 | ENST00000372899 | Q8IWV8 |
| ENSG00000024048 | ENST00000372901 | Q8IWV8 |
| ENSG00000024048 | ENST00000372903 | Q8IWV8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38225265 | 2024 | The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. | 1 |
| 38225265 | 2024 | The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. | 1 |
| 34922125 | 2022 | Burden of rare coding variants in an Italian cohort of familial multiple sclerosis. | 3 |
| 34922125 | 2022 | Burden of rare coding variants in an Italian cohort of familial multiple sclerosis. | 3 |
| 33288741 | 2020 | The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway. | 6 |
| 33288741 | 2020 | The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway. | 6 |
| 26940145 | 2016 | Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. | 2 |
| 26940145 | 2016 | Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. | 2 |
| 21573678 | 2011 | Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. | 4 |
| 21573678 | 2011 | Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. | 4 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 14585983 | 2003 | Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. | 75 |
| 14585983 | 2003 | Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. | 75 |
Citation
Dessen P
UBR2 (ubiquitin protein ligase E3 component n-recognin 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54747/ubr2-(ubiquitin-protein-ligase-e3-component-n-recognin-2)
