Identity
HGNC
LOCATION
13q34
LOCUSID
ALIAS
HUPF3A,RENT3A,UPF3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 65110
MIM: 605530
HGNC: 20332
Ensembl: ENSG00000169062
Variants:
dbSNP: 65110
ClinVar: 65110
TCGA: ENSG00000169062
COSMIC: UPF3A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169062 | ENST00000351487 | Q9H1J1 |
| ENSG00000169062 | ENST00000375299 | Q9H1J1 |
| ENSG00000169062 | ENST00000492270 | A0A087WZ33 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36807382 | 2023 | Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis. | 2 |
| 36807382 | 2023 | Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis. | 2 |
| 35451084 | 2022 | Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. | 12 |
| 35451102 | 2022 | Mammalian UPF3A and UPF3B can activate nonsense-mediated mRNA decay independently of their exon junction complex binding. | 16 |
| 35640974 | 2022 | Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation. | 6 |
| 35451084 | 2022 | Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. | 12 |
| 35451102 | 2022 | Mammalian UPF3A and UPF3B can activate nonsense-mediated mRNA decay independently of their exon junction complex binding. | 16 |
| 35640974 | 2022 | Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation. | 6 |
| 32718059 | 2020 | (Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A. | 2 |
| 32718059 | 2020 | (Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A. | 2 |
| 30977118 | 2019 | U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. | 11 |
| 30977118 | 2019 | U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. | 11 |
| 19503078 | 2009 | A UPF3-mediated regulatory switch that maintains RNA surveillance. | 67 |
| 19503078 | 2009 | A UPF3-mediated regulatory switch that maintains RNA surveillance. | 67 |
| 17803942 | 2007 | Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. | 46 |
Citation
Dessen P
UPF3A (UPF3A regulator of nonsense mediated mRNA decay)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54757/upf3a-(upf3a-regulator-of-nonsense-mediated-mrna-decay)
