Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
CIMDAG,SKD1,SKD1A,SKD2,VPS4,VPS4-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27183
MIM: 609982
HGNC: 13488
Ensembl: ENSG00000132612
Variants:
dbSNP: 27183
ClinVar: 27183
TCGA: ENSG00000132612
COSMIC: VPS4A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000132612 | ENST00000254950 | Q9UN37 |
| ENSG00000132612 | ENST00000254950 | A0A024R705 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37931722 | 2024 | CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma. | 2 |
| 38687820 | 2024 | The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission. | 0 |
| 37931722 | 2024 | CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma. | 2 |
| 38687820 | 2024 | The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission. | 0 |
| 36042696 | 2022 | Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4. | 5 |
| 36042696 | 2022 | Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4. | 5 |
| 33460484 | 2021 | VPS4A mutation in syndromic congenital hemolytic anemia without obvious signs of dyserythropoiesis. | 1 |
| 34145027 | 2021 | Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress. | 10 |
| 34281622 | 2021 | The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei. | 10 |
| 33460484 | 2021 | VPS4A mutation in syndromic congenital hemolytic anemia without obvious signs of dyserythropoiesis. | 1 |
| 34145027 | 2021 | Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress. | 10 |
| 34281622 | 2021 | The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei. | 10 |
| 31930723 | 2020 | Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. | 19 |
| 33186543 | 2020 | VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. | 14 |
| 33186545 | 2020 | De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment. | 26 |
Citation
Dessen P
VPS4A (vacuolar protein sorting 4 homolog A)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54768/vps4a-(vacuolar-protein-sorting-4-homolog-a)
