WDTC1 (WD and tetratricopeptide repeats 1)

2014-08-01  

Identity

HGNC
WDTC1
LOCATION
1p36.11
LOCUSID
23038
ALIAS
ADP,DCAF9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23038
HGNC: 29175
Ensembl: ENSG00000142784

Variants:

dbSNP: 23038
ClinVar: 23038
TCGA: ENSG00000142784
COSMIC: WDTC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142784ENST00000319394Q8N5D0
ENSG00000142784ENST00000361771Q8N5D0
ENSG00000142784ENST00000447062Q8N5D0
ENSG00000142784ENST00000472249H0YEI6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
271137642016The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.10
192381442009WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake.7
192381442009WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake.7
235129462013Adipose tissue expression of adipose (WDTC1) gene is associated with lower fat mass and enhanced insulin sensitivity in humans.3

Citation

Dessen P

WDTC1 (WD and tetratricopeptide repeats 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54781/wdtc1-(wd-and-tetratricopeptide-repeats-1)