Identity
HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
PHA2B,PRKWNK4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 65266
MIM: 601844
HGNC: 14544
Ensembl: ENSG00000126562
Variants:
dbSNP: 65266
ClinVar: 65266
TCGA: ENSG00000126562
COSMIC: WNK4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000126562 | ENST00000246914 | Q96J92 |
| ENSG00000126562 | ENST00000587745 | K7EPB3 |
| ENSG00000126562 | ENST00000591448 | K7ENT7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA213 | KCNJ1 | Gene | Pathway | associated | 23788015 | ||
| PA305 | SCNN1A | Gene | Pathway | associated | 23788015 | ||
| PA306 | SCNN1B | Gene | Pathway | associated | 23788015 | ||
| PA307 | SCNN1G | Gene | Pathway | associated | 23788015 | ||
| PA321 | SLC12A3 | Gene | Pathway | associated | 23788015 | ||
| PA33782 | WNK1 | Gene | Pathway | associated | 23788015 | ||
| PA38243 | STK39 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38764295 | 2024 | Downregulation of WNK4 expression facilitates the proliferation of gastric cancer cells via activation of the STAT3 signaling pathway. | 0 |
| 38764295 | 2024 | Downregulation of WNK4 expression facilitates the proliferation of gastric cancer cells via activation of the STAT3 signaling pathway. | 0 |
| 37285722 | 2023 | Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4. | 0 |
| 37481568 | 2023 | KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway. | 0 |
| 37285722 | 2023 | Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4. | 0 |
| 37481568 | 2023 | KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway. | 0 |
| 30718414 | 2019 | Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling. | 27 |
| 30931564 | 2019 | Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation. | 3 |
| 31044551 | 2019 | A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4. | 3 |
| 30718414 | 2019 | Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling. | 27 |
| 30931564 | 2019 | Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation. | 3 |
| 31044551 | 2019 | A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4. | 3 |
| 29148820 | 2018 | A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4. | 2 |
| 29846116 | 2018 | Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC. | 31 |
| 29148820 | 2018 | A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4. | 2 |
Citation
Dessen P
WNK4 (WNK lysine deficient protein kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54785/wnk4-(wnk-lysine-deficient-protein-kinase-4)
