ZFAT (zinc finger and AT-hook domain containing)

2014-08-01  

Identity

HGNC
LOCATION
8q24.22
LOCUSID
ALIAS
AITD3,ZFAT1,ZNF406
FUSION GENES

Other Information

Locus ID:

NCBI: 57623
MIM: 610931
HGNC: 19899
Ensembl: ENSG00000066827

Variants:

dbSNP: 57623
ClinVar: 57623
TCGA: ENSG00000066827
COSMIC: ZFAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066827ENST00000377838Q9P243
ENSG00000066827ENST00000429442F8W7M8
ENSG00000066827ENST00000518191E5RJT2
ENSG00000066827ENST00000519827H0YC51
ENSG00000066827ENST00000520214Q9P243
ENSG00000066827ENST00000520356E9PBN4
ENSG00000066827ENST00000520727Q9P243
ENSG00000066827ENST00000521673H0YBJ1
ENSG00000066827ENST00000522257E5RGN2
ENSG00000066827ENST00000523243E5RH37
ENSG00000066827ENST00000523399Q9P243
ENSG00000066827ENST00000523924E5RJL9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198479242010Detecting rare variants for complex traits using family and unrelated data.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228949092012A genome-wide approach reveals novel imprinted genes expressed in the human placenta.39
205495152010Genome-wide searching of rare genetic variants in WTCCC data.29
152948722004SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.25
227066872012Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies.16
191620262009ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells.15
206450172010ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model.4
204534412010Recent advances in the association studies of autoimmune thyroid disease and the functional characterization of AITD-related transcription factor ZFAT.2
258018602015Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.2

Citation

Dessen P

ZFAT (zinc finger and AT-hook domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54797/zfat-(zinc-finger-and-at-hook-domain-containing)