HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)

2014-08-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
HSE,RODH,SDR9C6

Other Information

Locus ID:

NCBI: 8630
MIM: 606623
HGNC: 23316
Ensembl: ENSG00000025423

Variants:

dbSNP: 8630
ClinVar: 8630
TCGA: ENSG00000025423
COSMIC: HSD17B6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025423ENST00000322165O14756
ENSG00000025423ENST00000322165A0A024RB43
ENSG00000025423ENST00000554150O14756
ENSG00000025423ENST00000554150A0A024RB43
ENSG00000025423ENST00000554155G3V3Y9
ENSG00000025423ENST00000554643O14756
ENSG00000025423ENST00000554643A0A024RB43
ENSG00000025423ENST00000555159O14756
ENSG00000025423ENST00000555159A0A024RB43
ENSG00000025423ENST00000555805O14756
ENSG00000025423ENST00000555805A0A024RB43
ENSG00000025423ENST00000556650G3V508

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373301352023HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.0
373301352023HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.0
327321742020Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias.4
327321742020Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias.4
254222942015Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population.14
254222942015Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population.14
242442762013Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants.40
242442762013Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants.40
221141942011Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer.28
221141942011Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer.28
202003322010Family-based analysis of candidate genes for polycystic ovary syndrome.47
210392822010Polymorphisms of the HSD17B6 and HSD17B5 genes in Chinese women with polycystic ovary syndrome.4
210392822010Polymorphisms of the HSD17B6 and HSD17B5 genes in Chinese women with polycystic ovary syndrome.4
202003322010Family-based analysis of candidate genes for polycystic ovary syndrome.47
210392822010Polymorphisms of the HSD17B6 and HSD17B5 genes in Chinese women with polycystic ovary syndrome.4

Citation

Dessen P

HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54826/hsd17b6-(hydroxysteroid-17-beta-dehydrogenase-6)