LUC7L2 (LUC7 like 2, pre-mRNA splicing factor)

2014-08-01  

Identity

HGNC
LUC7L2
LOCATION
7q34
LOCUSID
51631
ALIAS
CGI-59,CGI-74,LUC7B2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51631
MIM: 613056
HGNC: 21608
Ensembl: ENSG00000146963

Variants:

dbSNP: 51631
ClinVar: 51631
TCGA: ENSG00000146963
COSMIC: LUC7L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146963ENST00000263545Q9Y383
ENSG00000146963ENST00000354926Q9Y383
ENSG00000146963ENST00000456182F8WEU3
ENSG00000146963ENST00000541170Q9Y383
ENSG00000146963ENST00000608368V9GZ75
ENSG00000146963ENST00000619796Q9Y383

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384775072024Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention.1
384775072024Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention.1
338528592021Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.15
338528932021Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.27
338528592021Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.15
338528932021Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.27
244294982014Recurrent genetic defects on chromosome 7q in myeloid neoplasms.22
244294982014Recurrent genetic defects on chromosome 7q in myeloid neoplasms.22

Citation

Dessen P

LUC7L2 (LUC7 like 2, pre-mRNA splicing factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54830/luc7l2-(luc7-like-2-pre-mrna-splicing-factor)