B4GALT3 (beta-1,4-galactosyltransferase 3)

2014-08-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
beta4Gal-T3
FUSION GENES

Other Information

Locus ID:

NCBI: 8703
MIM: 604014
HGNC: 926
Ensembl: ENSG00000158850

Variants:

dbSNP: 8703
ClinVar: 8703
TCGA: ENSG00000158850
COSMIC: B4GALT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158850ENST00000319769O60512
ENSG00000158850ENST00000319769A0A384NY44
ENSG00000158850ENST00000367998O60512
ENSG00000158850ENST00000367998A0A384NY44
ENSG00000158850ENST00000622395O60512
ENSG00000158850ENST00000622395A0A384NY44

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
Other types of O-glycan biosynthesisKEGGko00514
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
N-Glycan biosynthesisKEGGhsa00510
Other types of O-glycan biosynthesisKEGGhsa00514
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGhsa_M00071
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGM00071
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340501132021Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting β-1, 4-galactosyltransferase III by sponging miR-338-3p.4
340501132021Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting β-1, 4-galactosyltransferase III by sponging miR-338-3p.4
322022332020B4GALT3 promotes cell proliferation and invasion in glioblastoma.8
322022332020B4GALT3 promotes cell proliferation and invasion in glioblastoma.8
305616052019Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.1
305616052019Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.1
293355512018Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer.450
303121732018Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.32
293355512018Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer.450
303121732018Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.32
269876232016B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.30
279009942016Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma.4
269876232016B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.30
279009942016Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma.4
256592962015β-1,4-Galactosyltransferase III suppresses extravillous trophoblast invasion through modifying β1-integrin glycosylation.16

Citation

Dessen P

B4GALT3 (beta-1,4-galactosyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54844/b4galt3-(beta-1-4-galactosyltransferase-3)