NOXO1 (NADPH oxidase organizer 1)

2014-09-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
P41NOX,P41NOXA,P41NOXB,P41NOXC,SH3PXD5,SNX28

Other Information

Locus ID:

NCBI: 124056
MIM: 611256
HGNC: 19404
Ensembl: ENSG00000196408

Variants:

dbSNP: 124056
ClinVar: 124056
TCGA: ENSG00000196408
COSMIC: NOXO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196408ENST00000354249Q8NFA2
ENSG00000196408ENST00000356120Q8NFA2
ENSG00000196408ENST00000397280Q8NFA2
ENSG00000196408ENST00000566005Q8NFA2
ENSG00000196408ENST00000567471H3BN18

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369020942023Overexpression of a Novel Noxo1 Mutant Increases Ros Production and Noxo1 Relocalisation.1
380155252023DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration.0
369020942023Overexpression of a Novel Noxo1 Mutant Increases Ros Production and Noxo1 Relocalisation.1
380155252023DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration.0
347428712022CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression.12
347428712022CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression.12
293111512018Tks adaptor proteins at a glance.22
293111512018Tks adaptor proteins at a glance.22
286259202017C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.3
289448932017Pigment epithelium‑derived factor protects human glomerular mesangial cells from diabetes via NOXO1‑iNOS suppression.0
286259202017C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.3
289448932017Pigment epithelium‑derived factor protects human glomerular mesangial cells from diabetes via NOXO1‑iNOS suppression.0
239754212014TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.71
239754212014TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.71
233221652013NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation.12

Citation

Dessen P

NOXO1 (NADPH oxidase organizer 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54846/noxo1-(nadph-oxidase-organizer-1)