Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
PI4K-ALPHA,PIK4CA,PMGYCHA,pi4K230
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5297
MIM: 600286
HGNC: 8983
Ensembl: ENSG00000241973
Variants:
dbSNP: 5297
ClinVar: 5297
TCGA: ENSG00000241973
COSMIC: PI4KA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000241973 | ENST00000255882 | P42356 |
| ENSG00000241973 | ENST00000399213 | A8MTF1 |
| ENSG00000241973 | ENST00000449120 | C9JLI1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37390900 | 2023 | Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement. | 2 |
| 37453227 | 2023 | PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases. | 4 |
| 37813099 | 2023 | CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation. | 0 |
| 37979461 | 2023 | Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease. | 2 |
| 37996444 | 2023 | Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth. | 0 |
| 37390900 | 2023 | Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement. | 2 |
| 37453227 | 2023 | PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases. | 4 |
| 37813099 | 2023 | CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation. | 0 |
| 37979461 | 2023 | Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease. | 2 |
| 37996444 | 2023 | Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth. | 0 |
| 36341355 | 2022 | A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression. | 0 |
| 36341355 | 2022 | A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression. | 0 |
| 34415310 | 2021 | Biallelic PI4KA variants cause neurological, intestinal and immunological disease. | 10 |
| 34415322 | 2021 | Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy. | 11 |
| 34504076 | 2021 | Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. | 24 |
Citation
Dessen P
PI4KA (phosphatidylinositol 4-kinase alpha)
Atlas Genet Cytogenet Oncol Haematol. 2014-09-01
Online version: http://atlasgeneticsoncology.org/gene/54852/pi4ka-(phosphatidylinositol-4-kinase-alpha)
