SERPINB1 (serpin family B member 1)

2014-09-01 Dessen P Affiliation

Identity

HGNC

SERPINB1

LOCATION

6p25.2

LOCUSID

1992

ALIAS

EI,ELANH2,HEL-S-27,HEL57,LEI,M/NEI,MNEI,PI-2,PI2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1992
MIM: 130135
HGNC: 3311
Ensembl: ENSG00000021355

Variants:

dbSNP: 1992
ClinVar: 1992
TCGA: ENSG00000021355
COSMIC: SERPINB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000021355	ENST00000380739	P30740
ENSG00000021355	ENST00000380739	V9HWH1

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36730076	2023	A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.	3
36730076	2023	A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.	3
35291946	2022	SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.	2
35291946	2022	SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.	2
32903749	2020	A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and β-Cell Function in Egyptian Type 2 Diabetic Patients.	5
32903749	2020	A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and β-Cell Function in Egyptian Type 2 Diabetic Patients.	5
30610107	2019	Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.	14
30692621	2019	SERPINB1-mediated checkpoint of inflammatory caspase activation.	59
30843084	2019	Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.	11
30610107	2019	Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.	14
30692621	2019	SERPINB1-mediated checkpoint of inflammatory caspase activation.	59
30843084	2019	Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.	11
29967939	2018	Sex-specific genetic predictors of Alzheimer's disease biomarkers.	59
29967939	2018	Sex-specific genetic predictors of Alzheimer's disease biomarkers.	59
28005267	2017	Human gingiva transcriptome during wound healing.	14

Citation

Dessen P

SERPINB1 (serpin family B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54855/serpinb1-(serpin-family-b-member-1)