GPM6B (glycoprotein M6B)

2014-09-01 Affiliation

Identity

HGNC

GPM6B

LOCATION

Xp22.2

LOCUSID

2824

ALIAS

M6B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2824
MIM: 300051
HGNC: 4461
Ensembl: ENSG00000046653

Variants:

dbSNP: 2824
ClinVar: 2824
TCGA: ENSG00000046653
COSMIC: GPM6B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000046653	ENST00000316715	Q13491
ENSG00000046653	ENST00000355135	Q13491
ENSG00000046653	ENST00000355135	A0A024RBX1
ENSG00000046653	ENST00000356942	Q13491
ENSG00000046653	ENST00000356942	A0A024RBV7
ENSG00000046653	ENST00000398361	B7Z248
ENSG00000046653	ENST00000454189	Q13491
ENSG00000046653	ENST00000468080	C9JZE8
ENSG00000046653	ENST00000475307	C9J028
ENSG00000046653	ENST00000493085	C9J8H8
ENSG00000046653	ENST00000493677	B7Z613

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33294057	2020	GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity.	2
33294057	2020	GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity.	2
30372567	2019	Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation.	14
30372567	2019	Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation.	14
24696529	2014	Breast carcinoma progression and tumour vascular markers related to apoptotic mechanisms.	5
24916915	2014	Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes.	12
25113253	2014	Vascular marker expression during the development of various types of gynaecological malignancy.	4
24696529	2014	Breast carcinoma progression and tumour vascular markers related to apoptotic mechanisms.	5
24916915	2014	Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes.	12
25113253	2014	Vascular marker expression during the development of various types of gynaecological malignancy.	4
23950870	2013	Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes.	9
23950870	2013	Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes.	9
21638316	2011	GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.	31
21638316	2011	GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.	31
18581270	2009	Membrane glycoprotein M6B interacts with the human serotonin transporter.	20

Citation

Dessen P

GPM6B (glycoprotein M6B)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54858/gpm6b-(glycoprotein-m6b)