Identity
HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
HSAN2,HSN2,KDP,PPP1R167,PRKWNK1,PSK,p65
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 65125
MIM: 605232
HGNC: 14540
Ensembl: ENSG00000060237
Variants:
dbSNP: 65125
ClinVar: 65125
TCGA: ENSG00000060237
COSMIC: WNK1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134875400 | WNK4 | Gene | Pathway | associated | 23788015 | ||
| PA213 | KCNJ1 | Gene | Pathway | associated | 23788015 | ||
| PA305 | SCNN1A | Gene | Pathway | associated | 23788015 | ||
| PA306 | SCNN1B | Gene | Pathway | associated | 23788015 | ||
| PA307 | SCNN1G | Gene | Pathway | associated | 23788015 | ||
| PA33784 | WNK3 | Gene | Pathway | associated | 23788015 | ||
| PA38243 | STK39 | Gene | Pathway | associated | 23788015 | ||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 18591455 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 18591455 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38287200 | 2024 | Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis. | 3 |
| 38599542 | 2024 | The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1. | 0 |
| 38287200 | 2024 | Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis. | 3 |
| 38599542 | 2024 | The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1. | 0 |
| 35138567 | 2023 | Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma. | 2 |
| 37307465 | 2023 | WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly. | 1 |
| 37544354 | 2023 | WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells. | 0 |
| 37895227 | 2023 | A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1. | 0 |
| 35138567 | 2023 | Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma. | 2 |
| 37307465 | 2023 | WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly. | 1 |
| 37544354 | 2023 | WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells. | 0 |
| 37895227 | 2023 | A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1. | 0 |
| 35150137 | 2022 | The WNK1 kinase regulates the stability of transcription factors during wound healing of human corneal epithelial cells. | 0 |
| 35849656 | 2022 | WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia. | 3 |
| 36151370 | 2022 | WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway. | 1 |
Citation
Dessen P
WNK1 (WNK lysine deficient protein kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-09-01
Online version: http://atlasgeneticsoncology.org/gene/54859/wnk1-(wnk-lysine-deficient-protein-kinase-1)
