WNK1 (WNK lysine deficient protein kinase 1)

2014-09-01  

Identity

HGNC
WNK1
LOCATION
12p13.33
LOCUSID
65125
ALIAS
HSAN2,HSN2,KDP,PPP1R167,PRKWNK1,PSK,p65
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65125
MIM: 605232
HGNC: 14540
Ensembl: ENSG00000060237

Variants:

dbSNP: 65125
ClinVar: 65125
TCGA: ENSG00000060237
COSMIC: WNK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060237ENST00000315939Q9H4A3
ENSG00000060237ENST00000447667F6UYG0
ENSG00000060237ENST00000534872H0YH68
ENSG00000060237ENST00000535572F5GWT4
ENSG00000060237ENST00000535698H0YFP5
ENSG00000060237ENST00000543065H0YFK5
ENSG00000060237ENST00000544559H0YF81
ENSG00000060237ENST00000544965H0YFF1
ENSG00000060237ENST00000545285H0YH79
ENSG00000060237ENST00000574564A0A0B4J299
ENSG00000060237ENST00000574679I3L251

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134875400WNK4GenePathwayassociated23788015
PA213KCNJ1GenePathwayassociated23788015
PA305SCNN1AGenePathwayassociated23788015
PA306SCNN1BGenePathwayassociated23788015
PA307SCNN1GGenePathwayassociated23788015
PA33784WNK3GenePathwayassociated23788015
PA38243STK39GenePathwayassociated23788015
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD18591455
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD18591455

References

Pubmed IDYearTitleCitations
382872002024Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.3
385995422024The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.0
382872002024Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.3
385995422024The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.0
351385672023Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.2
373074652023WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.1
375443542023WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.0
378952272023A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.0
351385672023Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.2
373074652023WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.1
375443542023WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.0
378952272023A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.0
351501372022The WNK1 kinase regulates the stability of transcription factors during wound healing of human corneal epithelial cells.0
358496562022WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.3
361513702022WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway.1

Citation

Dessen P

WNK1 (WNK lysine deficient protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54859/wnk1-(wnk-lysine-deficient-protein-kinase-1)