Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51024
MIM: 609003
HGNC: 21689
Ensembl: ENSG00000214253
Variants:
dbSNP: 51024
ClinVar: 51024
TCGA: ENSG00000214253
COSMIC: FIS1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Mitophagy - animal | KEGG | ko04137 |
| Mitophagy - animal | KEGG | hsa04137 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38409448 | 2024 | NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. | 0 |
| 38409448 | 2024 | NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. | 0 |
| 37479690 | 2023 | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | 12 |
| 37589160 | 2023 | Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. | 4 |
| 37777154 | 2023 | A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission. | 3 |
| 37479690 | 2023 | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | 12 |
| 37589160 | 2023 | Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. | 4 |
| 37777154 | 2023 | A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission. | 3 |
| 33890233 | 2022 | FIS1 Overexpression Is Correlated with Tumor Metastasis in Gastric Adenocarcinoma. | 5 |
| 35275026 | 2022 | Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1. | 4 |
| 35290083 | 2022 | DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. | 45 |
| 35678336 | 2022 | PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. | 8 |
| 36044022 | 2022 | Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics. | 10 |
| 36272645 | 2022 | Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission. | 7 |
| 33890233 | 2022 | FIS1 Overexpression Is Correlated with Tumor Metastasis in Gastric Adenocarcinoma. | 5 |
Citation
Dessen P
FIS1 (fission, mitochondrial 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-09-01
Online version: http://atlasgeneticsoncology.org/gene/54877/fis1-(fission-mitochondrial-1)
