CYP4F2 (cytochrome P450 family 4 subfamily F member 2)

2014-09-01 Affiliation

Identity

HGNC

CYP4F2

LOCATION

19p13.12

LOCUSID

8529

ALIAS

CPF2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8529
MIM: 604426
HGNC: 2645
Ensembl: ENSG00000186115

Variants:

dbSNP: 8529
ClinVar: 8529
TCGA: ENSG00000186115
COSMIC: CYP4F2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186115	ENST00000011989	A0A0A0MQR0
ENSG00000186115	ENST00000221700	P78329
ENSG00000186115	ENST00000586927	K7EK90
ENSG00000186115	ENST00000587671	K7EPM0
ENSG00000186115	ENST00000589654	K7EQI8

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)	REACTOME	R-HSA-2142691
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Fatty acids	REACTOME	R-HSA-211935
Eicosanoids	REACTOME	R-HSA-211979
Miscellaneous substrates	REACTOME	R-HSA-211958

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA126	CYP2C9	Gene	DataAnnotation	associated
PA130620651	anthracyclines and related substances	Chemical	ClinicalAnnotation	associated		PD	21900104, 23441093
PA133787052	VKORC1	Gene	DataAnnotation	associated
PA153619833	Peripheral Vascular Diseases	Disease	ClinicalAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA164713404	Vitamin K	Chemical	ClinicalAnnotation, VipGene	associated	PK		27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 18841274, 19297519, 28521079
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated		PD	24418943, 25712182
PA165816543	CYP2C9*2	Haplotype	GuidelineAnnotation	associated
PA165816544	CYP2C9*3	Haplotype	GuidelineAnnotation	associated
PA165816546	CYP2C9*5	Haplotype	GuidelineAnnotation	associated
PA165816547	CYP2C9*6	Haplotype	GuidelineAnnotation	associated
PA165816549	CYP2C9*8	Haplotype	GuidelineAnnotation	associated
PA165816552	CYP2C9*11	Haplotype	GuidelineAnnotation	associated
PA165860687	CYP4F2*3	Haplotype	VipGene	associated			19132230, 20072124, 20182420, 20555338, 22417713, 22855348, 24956252, 25042728, 14638353
PA166122486	db-289	Chemical	VipGene	associated
PA166123298	over-anticoagulation	Disease	ClinicalAnnotation	associated		PD	22417713, 23104259, 24911077, 28049362
PA166129532	time to therapeutic inr	Disease	VariantAnnotation	associated		PD	29396738
PA166154157	rs12777823	Variant	GuidelineAnnotation	associated
PA166155091	rs9923231	Variant	GuidelineAnnotation	associated
PA166155381	rs2108622	Variant	GuidelineAnnotation, VipGene	associated			19132230, 20072124, 20182420, 20555338, 22417713, 22855348, 24956252, 25042728, 14638353
PA166197681	Vitamin K1	Chemical	ClinicalAnnotation	associated	PK		31134657
PA28660	GGCX	Gene	DataAnnotation	associated
PA443459	Atrial Fibrillation	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	19270263, 19578179, 22486182, 23510058, 24956252, 25042728, 25519826, 29396738, 29432897, 29479633
PA444417	Hemorrhage	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	21900104, 23441093
PA445848	Thromboembolism	Disease	ClinicalAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA446997	Intracranial Hemorrhages	Disease	ClinicalAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA447288	Essential hypertension	Disease	VipGene	associated			18971550
PA447298	venous thromboembolism	Disease	ClinicalAnnotation	associated	PK	PD	18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA448497	aspirin	Chemical	ClinicalAnnotation	associated		PD	24418943, 25712182
PA449045	clofibrate	Chemical	VipGene	associated			11061988, 11997390, 15753130, 17142457, 10860554
PA449053	clopidogrel	Chemical	ClinicalAnnotation	associated		PD	24418943, 25712182
PA450146	ketoconazole	Chemical	VipGene	associated			15753130
PA450272	lovastatin	Chemical	VipGene	associated			17142457
PA450921	phenprocoumon	Chemical	ClinicalAnnotation	associated	PK	PD	21063236, 23510058
PA451900	vitamin e	Chemical	ClinicalAnnotation, VipGene	associated	PK		15753130, 18433732, 11997390, 17341693, 20861217, 24138531, 24759732
PA451906	warfarin	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	18391101, 18971550, 24984178, 27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 17341693, 18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22417713, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 24911077, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28079798, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29396738, 29432897, 29875668
PA452632	acenocoumarol	Chemical	ClinicalAnnotation, DataAnnotation, Literature, VipGene	associated		PD	27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 19132230, 19270263, 19578179, 22486182, 23510058, 24956252, 25042728, 25089947, 25519826, 29432897, 29479633
PA55	APOE	Gene	DataAnnotation	associated

References

Pubmed ID	Year	Title	Citations
19300499	2009	A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.	211
19300499	2009	A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.	211
18250228	2008	CYP4F2 genetic variant alters required warfarin dose.	157
18250228	2008	CYP4F2 genetic variant alters required warfarin dose.	157
19297519	2009	CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20072124	2010	Genetic and clinical predictors of warfarin dose requirements in African Americans.	78
18391101	2008	A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.	57
18391101	2008	A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.	57
20504253	2010	Combined CYP2C9, VKORC1 and CYP4F2 frequencies among racial and ethnic groups.	52

Citation

Dessen P

CYP4F2 (cytochrome P450 family 4 subfamily F member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54891/cyp4f2-(cytochrome-p450-family-4-subfamily-f-member-2)