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CD2AP gene encodes for an adaptor protein with high homology to Cin85. It was originally cloned as CD2 interacting protein and, in an independent study, as p130-Cas interacting protein. It contains three SH3 domains, a proline-rich motif and a coiled-coil domain that allow it to form complexes with numerous proteins and to participate in different physiological processes. Several evidences suggest that it links cell surface proteins and specialized junctions with the actin cytoskeleton and that it regulates the assembly of actin filaments to guide cell shape and movements.
CD2AP (CD2 associated protein)
Atlas Genet Cytogenet Oncol Haematol. 2017-11-01
Online version: http://atlasgeneticsoncology.org/gene/54896/cd2ap-(cd2-associated-protein)