Identity
HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
MPZL1b,PZR,PZR1b,PZRa,PZRb
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9019
MIM: 604376
HGNC: 7226
Ensembl: ENSG00000197965
Variants:
dbSNP: 9019
ClinVar: 9019
TCGA: ENSG00000197965
COSMIC: MPZL1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell adhesion molecules (CAMs) | KEGG | ko04514 |
| Cell adhesion molecules (CAMs) | KEGG | hsa04514 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37183407 | 2023 | MPZL1 Promotes Lung Adenocarcinoma Progression by Enhancing Tumor Proliferation, Invasion, Migration, and Suppressing Immune Function via Transforming Growth Factor-β1. | 1 |
| 37183407 | 2023 | MPZL1 Promotes Lung Adenocarcinoma Progression by Enhancing Tumor Proliferation, Invasion, Migration, and Suppressing Immune Function via Transforming Growth Factor-β1. | 1 |
| 35637954 | 2022 | LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome. | 4 |
| 35727197 | 2022 | MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer. | 5 |
| 35637954 | 2022 | LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome. | 4 |
| 35727197 | 2022 | MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer. | 5 |
| 30877754 | 2019 | PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation. | 6 |
| 31233194 | 2019 | MPZL1 promotes tumor cell proliferation and migration via activation of Src kinase in ovarian cancer. | 10 |
| 31322261 | 2019 | MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells. | 5 |
| 30877754 | 2019 | PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation. | 6 |
| 31233194 | 2019 | MPZL1 promotes tumor cell proliferation and migration via activation of Src kinase in ovarian cancer. | 10 |
| 31322261 | 2019 | MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells. | 5 |
| 30392906 | 2018 | Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1. | 2 |
| 30392906 | 2018 | Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1. | 2 |
| 28912526 | 2017 | MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells. | 10 |
Citation
Dessen P
MPZL1 (myelin protein zero like 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-10-01
Online version: http://atlasgeneticsoncology.org/gene/54902/mpzl1-(myelin-protein-zero-like-1)
