CEP152 (centrosomal protein 152)

2014-10-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
MCPH4,MCPH9,SCKL5
FUSION GENES

Other Information

Locus ID:

NCBI: 22995
MIM: 613529
HGNC: 29298
Ensembl: ENSG00000103995

Variants:

dbSNP: 22995
ClinVar: 22995
TCGA: ENSG00000103995
COSMIC: CEP152

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103995ENST00000325747O94986
ENSG00000103995ENST00000380950O94986
ENSG00000103995ENST00000399334O94986
ENSG00000103995ENST00000558591H0YN91
ENSG00000103995ENST00000560322A0A075B719
ENSG00000103995ENST00000561245H0YMG1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377074732023Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning.3
377074732023Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning.3
341563112021Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.0
341563112021Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.0
321522522020Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.15
321522522020Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.15
308583762019Molecular architecture of a cylindrical self-assembly at human centrosomes.22
308583762019Molecular architecture of a cylindrical self-assembly at human centrosomes.22
289702582018Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation.11
289702582018Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation.11
249975972014Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.62
249975972014Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.62
233333162013Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex.64
236410732013Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.131
239361282013Cep63 and cep152 cooperate to ensure centriole duplication.49

Citation

Dessen P

CEP152 (centrosomal protein 152)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54930/cep152-(centrosomal-protein-152)