CEP192 (centrosomal protein 192)

2014-10-01  

Identity

HGNC
CEP192
LOCATION
18p11.21
LOCUSID
55125
ALIAS
PPP1R62
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55125
MIM: 616426
HGNC: 25515
Ensembl: ENSG00000101639

Variants:

dbSNP: 55125
ClinVar: 55125
TCGA: ENSG00000101639
COSMIC: CEP192

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101639ENST00000325971A0A0A0MR42
ENSG00000101639ENST00000430049C9JT09
ENSG00000101639ENST00000506447Q8TEP8
ENSG00000101639ENST00000507064V9GYM2
ENSG00000101639ENST00000508150K7EQZ8
ENSG00000101639ENST00000510237H0Y966
ENSG00000101639ENST00000511820K7ENP4
ENSG00000101639ENST00000513432H0Y9P3
ENSG00000101639ENST00000585938K7ERF9
ENSG00000101639ENST00000589596K7ELX0
ENSG00000101639ENST00000589993K7EPA2

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
236410732013Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.81
182077422008The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.72
242778142013Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.69
179805962007Human Cep192 is required for mitotic centrosome and spindle assembly.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
250428042014The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.47
210977012010Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.35
249975972014Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.35
239329022013PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.32
275624532016Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.17

Citation

Dessen P

CEP192 (centrosomal protein 192)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54934/cep192-(centrosomal-protein-192)