CEP192 (centrosomal protein 192)

2014-10-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
PPP1R62
FUSION GENES

Other Information

Locus ID:

NCBI: 55125
MIM: 616426
HGNC: 25515
Ensembl: ENSG00000101639

Variants:

dbSNP: 55125
ClinVar: 55125
TCGA: ENSG00000101639
COSMIC: CEP192

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101639ENST00000325971A0A0A0MR42
ENSG00000101639ENST00000430049C9JT09
ENSG00000101639ENST00000506447Q8TEP8
ENSG00000101639ENST00000507064V9GYM2
ENSG00000101639ENST00000508150K7EQZ8
ENSG00000101639ENST00000510237H0Y966
ENSG00000101639ENST00000511820K7ENP4
ENSG00000101639ENST00000513432H0Y9P3
ENSG00000101639ENST00000585938K7ERF9
ENSG00000101639ENST00000589596K7ELX0
ENSG00000101639ENST00000589993K7EPA2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379817622024Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.0
379817622024Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.0
362383042022CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.1
362383042022CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.1
334435712021Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.18
334435712021Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.18
326233842020Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.11
326233842020Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.11
293481452018FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.13
293481452018FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.13
281887922017Recruitment of PP1 to the centrosomal scaffold protein CEP192.7
281887922017Recruitment of PP1 to the centrosomal scaffold protein CEP192.7
275624532016Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.36
275624532016Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.36
260125492015Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.19

Citation

Dessen P

CEP192 (centrosomal protein 192)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54934/cep192-(centrosomal-protein-192)