Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2869
MIM: 600870
HGNC: 4544
Ensembl: ENSG00000198873
Variants:
dbSNP: 2869
ClinVar: 2869
TCGA: ENSG00000198873
COSMIC: GRK5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198873 | ENST00000392870 | P34947 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164712445 | Antihypertensives | Chemical | ClinicalAnnotation | associated | PD | 18425130, 21127457 | |
| PA164712535 | Beta Blocking Agents | Chemical | ClinicalAnnotation | associated | PD | 18425130, 21127457 | |
| PA444368 | Heart Diseases | Disease | ClinicalAnnotation | associated | PD | 18425130, 21127457 | |
| PA444370 | Heart Failure | Disease | ClinicalAnnotation | associated | PD | ||
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | ||
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38206179 | 2024 | GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway. | 0 |
| 38822544 | 2024 | Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan. | 0 |
| 38206179 | 2024 | GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway. | 0 |
| 38822544 | 2024 | Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan. | 0 |
| 36584571 | 2023 | Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation. | 1 |
| 36584571 | 2023 | Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation. | 1 |
| 34871184 | 2022 | Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients. | 1 |
| 35412954 | 2022 | lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5. | 5 |
| 34871184 | 2022 | Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients. | 1 |
| 35412954 | 2022 | lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5. | 5 |
| 33321095 | 2021 | Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. | 8 |
| 33466800 | 2021 | GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. | 4 |
| 34268929 | 2021 | Association between gene polymorphism of GRK5 and breast cancer risk in Chinese population. | 1 |
| 33321095 | 2021 | Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. | 8 |
| 33466800 | 2021 | GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. | 4 |
Citation
Dessen P
GRK5 (G protein-coupled receptor kinase 5)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/54940/grk5-(g-protein-coupled-receptor-kinase-5)
