Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51804
MIM: 606342
HGNC: 10890
Ensembl: ENSG00000100625
Variants:
dbSNP: 51804
ClinVar: 51804
TCGA: ENSG00000100625
COSMIC: SIX4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100625 | ENST00000216513 | Q9UIU6 |
| ENSG00000100625 | ENST00000556952 | G3V2N2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transcriptional misregulation in cancer | KEGG | ko05202 |
| Transcriptional misregulation in cancer | KEGG | hsa05202 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36601689 | 2023 | SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression. | 2 |
| 37656231 | 2023 | Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction. | 1 |
| 36601689 | 2023 | SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression. | 2 |
| 37656231 | 2023 | Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction. | 1 |
| 35616130 | 2022 | IGF2BP3‑stabilized SIX4 promotes the proliferation, migration, invasion and tube formation of ovarian cancer cells. | 3 |
| 35616130 | 2022 | IGF2BP3‑stabilized SIX4 promotes the proliferation, migration, invasion and tube formation of ovarian cancer cells. | 3 |
| 32826305 | 2021 | Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4. | 20 |
| 33481352 | 2021 | Upregulation of SIX4 indicates poor clinical outcome and promotes tumor growth and cell metastasis in esophageal squamous cell carcinoma. | 5 |
| 32826305 | 2021 | Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4. | 20 |
| 33481352 | 2021 | Upregulation of SIX4 indicates poor clinical outcome and promotes tumor growth and cell metastasis in esophageal squamous cell carcinoma. | 5 |
| 32535033 | 2020 | Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. | 17 |
| 33046796 | 2020 | SIX4 promotes hepatocellular carcinoma metastasis through upregulating YAP1 and c-MET. | 21 |
| 32535033 | 2020 | Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. | 17 |
| 33046796 | 2020 | SIX4 promotes hepatocellular carcinoma metastasis through upregulating YAP1 and c-MET. | 21 |
| 31210312 | 2019 | MiRNA-621 inhibits the malignant progression of non-small cell lung cancer via targeting SIX4. | 7 |
Citation
Dessen P
SIX4 (SIX homeobox 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/54944/six4-(six-homeobox-4)
