SPAG5 (sperm associated antigen 5)

2014-11-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
DEEPEST,MAP126,hMAP126
FUSION GENES

Other Information

Locus ID:

NCBI: 10615
MIM: 615562
HGNC: 13452
Ensembl: ENSG00000076382

Variants:

dbSNP: 10615
ClinVar: 10615
TCGA: ENSG00000076382
COSMIC: SPAG5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076382ENST00000321765Q96R06
ENSG00000076382ENST00000378976K7ELC8
ENSG00000076382ENST00000536674F5GZT2
ENSG00000076382ENST00000578230J3QRL6
ENSG00000076382ENST00000578479J3KSV2
ENSG00000076382ENST00000580083J3QS12
ENSG00000076382ENST00000580567J3QRV8
ENSG00000076382ENST00000582076K7ELG0
ENSG00000076382ENST00000584206J3KTQ0

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
239531162013Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.79
176643312007Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity.59
208525892010CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.51
270370002016miR-539 inhibits prostate cancer progression by directly targeting SPAG5.27
273120512016SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.25
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
287517102017Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.16
180554572008Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin.14
248534252014SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway.14
115492622001Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins.13

Citation

Dessen P

SPAG5 (sperm associated antigen 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/54948/spag5-(sperm-associated-antigen-5)