CD177 (CD177 molecule)

2015-02-01  

Identity

HGNC
CD177
LOCATION
19q13.31
LOCUSID
57126
ALIAS
HNA-2a,HNA2A,NB1,NB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57126
MIM: 162860
HGNC: 30072
Ensembl: ENSG00000204936

Variants:

dbSNP: 57126
ClinVar: 57126
TCGA: ENSG00000204936
COSMIC: CD177

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204936ENST00000378012Q8N6Q3
ENSG00000204936ENST00000607855A0A087X113
ENSG00000204936ENST00000618265A0A087WVM2

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
vagina
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384741262024The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.1
384741262024The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.1
363521472023Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.1
363521472023Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.1
350635072022Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.2
350635072022Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.2
325318262021The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.11
337344542021Characterization of CD177-reactive iso- and auto-antibodies.3
345991872021CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.28
348791102021The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.7
325318262021The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.11
337344542021Characterization of CD177-reactive iso- and auto-antibodies.3
345991872021CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.28
348791102021The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.7
317771112020A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype.2

Citation

Dessen P

CD177 (CD177 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54964/js/css/lib/humanGenome