ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2)

2015-02-01 Affiliation

Identity

HGNC

ST6GALNAC2

LOCATION

17q25.1

LOCUSID

10610

ALIAS

SAITL1,SIAT7,SIAT7B,SIATL1,ST6GalNAII,STHM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10610
MIM: 610137
HGNC: 10867
Ensembl: ENSG00000070731

Variants:

dbSNP: 10610
ClinVar: 10610
TCGA: ENSG00000070731
COSMIC: ST6GALNAC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000070731	ENST00000225276	Q9UJ37
ENSG00000070731	ENST00000225276	A0A024R8M1
ENSG00000070731	ENST00000585390	K7EIW2
ENSG00000070731	ENST00000585736	K7EMI2
ENSG00000070731	ENST00000588120	K7EKT8
ENSG00000070731	ENST00000588920	K7EMM1

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	REACTOME	R-HSA-446193
Synthesis of substrates in N-glycan biosythesis	REACTOME	R-HSA-446219
Sialic acid metabolism	REACTOME	R-HSA-4085001
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709
Termination of O-glycan biosynthesis	REACTOME	R-HSA-977068

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28767179	2017	Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway.	48
29030743	2017	miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.	32
28767179	2017	Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway.	48
29030743	2017	miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.	32
26820593	2016	ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma.	11
27004849	2016	Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.	28
26820593	2016	ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma.	11
27004849	2016	Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.	28
24398680	2014	Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.	85
24520024	2014	An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.	56
24756995	2014	ST6GalNAcII mediates the invasive properties of breast carcinoma through PI3K/Akt/NF-κB signaling pathway.	14
24398680	2014	Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.	85
24520024	2014	An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.	56
24756995	2014	ST6GalNAcII mediates the invasive properties of breast carcinoma through PI3K/Akt/NF-κB signaling pathway.	14
23548905	2013	Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1.	33

Citation

Dessen P

ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54978/js/css/welcome