Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
FKSG80,GPR104,GPR81,HCA1,LACR1,TA-GPCR,TAGPCR
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27198
MIM: 606923
HGNC: 4532
Ensembl: ENSG00000196917
Variants:
dbSNP: 27198
ClinVar: 27198
TCGA: ENSG00000196917
COSMIC: HCAR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196917 | ENST00000432564 | Q9BXC0 |
| ENSG00000196917 | ENST00000432564 | A0A4Y1JWP1 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38334628 | 2024 | High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81. | 0 |
| 38334628 | 2024 | High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81. | 0 |
| 36622074 | 2023 | The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling. | 4 |
| 37391123 | 2023 | History and Function of the Lactate Receptor GPR81/HCAR1 in the Brain: A Putative Therapeutic Target for the Treatment of Cerebral Ischemia. | 4 |
| 37698122 | 2023 | Activation of GPR81 aggravated intestinal ischemia/reperfusion injury-induced acute lung injury via HMGB1-mediated neutrophil extracellular traps formation. | 2 |
| 36622074 | 2023 | The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling. | 4 |
| 37391123 | 2023 | History and Function of the Lactate Receptor GPR81/HCAR1 in the Brain: A Putative Therapeutic Target for the Treatment of Cerebral Ischemia. | 4 |
| 37698122 | 2023 | Activation of GPR81 aggravated intestinal ischemia/reperfusion injury-induced acute lung injury via HMGB1-mediated neutrophil extracellular traps formation. | 2 |
| 35182679 | 2022 | Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells. | 3 |
| 35240875 | 2022 | Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue. | 14 |
| 35428832 | 2022 | The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer. | 18 |
| 35775372 | 2022 | Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells. | 6 |
| 36084306 | 2022 | Insights into the regulation of podocyte and glomerular function by lactate and its metabolic sensor G-protein-coupled receptor 81. | 0 |
| 35182679 | 2022 | Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells. | 3 |
| 35240875 | 2022 | Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue. | 14 |
Citation
Dessen P
HCAR1 (hydroxycarboxylic acid receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2015-02-01
Online version: http://atlasgeneticsoncology.org/gene/54981/chromosome-explorer/submit-meetings/
