PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial)

2015-02-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
PEPCK,PEPCK-M,PEPCK2

Other Information

Locus ID:

NCBI: 5106
MIM: 614095
HGNC: 8725
Ensembl: ENSG00000100889

Variants:

dbSNP: 5106
ClinVar: 5106
TCGA: ENSG00000100889
COSMIC: PCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100889ENST00000216780Q16822
ENSG00000100889ENST00000216780A0A384MTT2
ENSG00000100889ENST00000396973Q16822
ENSG00000100889ENST00000545054Q16822
ENSG00000100889ENST00000558096H0YML5
ENSG00000100889ENST00000559171H0YMY3
ENSG00000100889ENST00000559250H0YM31
ENSG00000100889ENST00000559503H0YMA5
ENSG00000100889ENST00000559584H0YKC4
ENSG00000100889ENST00000559837H0YMU6
ENSG00000100889ENST00000560106H0YNH9
ENSG00000100889ENST00000560736H0YNG4
ENSG00000100889ENST00000561286Q16822

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Citrate cycle (TCA cycle)KEGGko00020
Pyruvate metabolismKEGGko00620
PPAR signaling pathwayKEGGko03320
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Glycolysis / GluconeogenesisKEGGhsa00010
Citrate cycle (TCA cycle)KEGGhsa00020
Pyruvate metabolismKEGGhsa00620
PPAR signaling pathwayKEGGhsa03320
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Metabolic pathwaysKEGGhsa01100
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386974492024Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.0
388905072024Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma.0
386974492024Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.0
388905072024Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma.0
357578412023Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway.5
375657372023AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.1
357578412023Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway.5
375657372023AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.1
355800792022Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells.2
359829072022Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia.1
360024492022Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells.3
355800792022Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells.2
359829072022Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia.1
360024492022Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells.3
338930832021Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.2

Citation

Dessen P

PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54985/pck2-(phosphoenolpyruvate-carboxykinase-2-mitochondrial)