SLC22A7 (solute carrier family 22 member 7)

2015-02-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
NLT,OAT2,hOAT11

Other Information

Locus ID:

NCBI: 10864
MIM: 604995
HGNC: 10971
Ensembl: ENSG00000137204

Variants:

dbSNP: 10864
ClinVar: 10864
TCGA: ENSG00000137204
COSMIC: SLC22A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137204ENST00000372574Q9Y694
ENSG00000137204ENST00000372585Q9Y694
ENSG00000137204ENST00000372589Q9Y694
ENSG00000137204ENST00000436107X6RDF7
ENSG00000137204ENST00000449231Q5T051
ENSG00000137204ENST00000451757Q5T047

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic anion transportREACTOMER-HSA-561048

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD28347776
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD28347776
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD28347776
PA448771capecitabineChemicalClinicalAnnotationassociatedPD28347776
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
320012362020Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).11
320819262020Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.12
320012362020Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).11
320819262020Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.12
289451552018In vitro studies with two human organic anion transporters: OAT2 and OAT7.4
292441912018The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes.7
296698242018Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics.2
299061292018Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.7
301351782018Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.10
289451552018In vitro studies with two human organic anion transporters: OAT2 and OAT7.4
292441912018The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes.7
296698242018Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics.2
299061292018Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.7
301351782018Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.10
283715062017Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.18

Citation

Dessen P

SLC22A7 (solute carrier family 22 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54990/chromosome-explorer/submit-meetings/