LAP3 (leucine aminopeptidase 3)

2015-02-01  

Identity

HGNC
LAP3
LOCATION
4p15.32
LOCUSID
51056
ALIAS
HEL-S-106,LAP,LAPEP,PEPS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51056
MIM: 170250
HGNC: 18449
Ensembl: ENSG00000002549

Variants:

dbSNP: 51056
ClinVar: 51056
TCGA: ENSG00000002549
COSMIC: LAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002549ENST00000226299P28838
ENSG00000002549ENST00000509583H0Y983
ENSG00000002549ENST00000513105H0Y9Q1
ENSG00000002549ENST00000606142P28838
ENSG00000002549ENST00000618908P28838

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Glutathione metabolismKEGGko00480
Arginine and proline metabolismKEGGhsa00330
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354048402022Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD.9
354048402022Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD.9
335018412021Urinary leucine aminopeptidase 3 in population environmentally exposed to airborne arsenic.0
338930832021Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.2
335018412021Urinary leucine aminopeptidase 3 in population environmentally exposed to airborne arsenic.0
338930832021Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.2
304175852019Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.21
304175852019Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.21
254532852015LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells.21
254532852015LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells.21
244776622014Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma.14
251207512014Expression of leucine aminopeptidase 3 (LAP3) correlates with prognosis and malignant development of human hepatocellular carcinoma (HCC).16
244776622014Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma.14
251207512014Expression of leucine aminopeptidase 3 (LAP3) correlates with prognosis and malignant development of human hepatocellular carcinoma (HCC).16
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

LAP3 (leucine aminopeptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54993/lap3-(leucine-aminopeptidase-3)