SLBP (stem-loop binding protein)

2015-02-01  

Identity

HGNC
SLBP
LOCATION
4p16.3
LOCUSID
7884
ALIAS
HBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7884
MIM: 602422
HGNC: 10904
Ensembl: ENSG00000163950

Variants:

dbSNP: 7884
ClinVar: 7884
TCGA: ENSG00000163950
COSMIC: SLBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163950ENST00000318386F8W8D3
ENSG00000163950ENST00000429429Q14493
ENSG00000163950ENST00000480936H7C4H8
ENSG00000163950ENST00000483348H0YAE8
ENSG00000163950ENST00000488267E7EUV9
ENSG00000163950ENST00000489418Q14493
ENSG00000163950ENST00000489418Q53XR2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of the SLBP Dependant Mature mRNAREACTOMER-HSA-159230
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAsREACTOMER-HSA-77588

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346459752022DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP.10
346459752022DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP.10
329602652020Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.4
329602652020Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.4
310070832019Knocking down miR-384 promotes growth and metastasis of osteosarcoma MG63 cells by targeting SLBP.13
310070832019Knocking down miR-384 promotes growth and metastasis of osteosarcoma MG63 cells by targeting SLBP.13
281180782017FEM1 proteins are ancient regulators of SLBP degradation.18
283067452017Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation.11
281180782017FEM1 proteins are ancient regulators of SLBP degradation.18
283067452017Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation.11
272031822016CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.21
272548192016DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase.14
274542922016Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication.4
277736722016Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.43
272031822016CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.21

Citation

Dessen P

SLBP (stem-loop binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54997/slbp-(stem-loop-binding-protein)