WDFY2 (WD repeat and FYVE domain containing 2)

2015-02-01  

Identity

HGNC
WDFY2
LOCATION
13q14.3
LOCUSID
115825
ALIAS
PROF,WDF2,ZFYVE22
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 115825
MIM: 610418
HGNC: 20482
Ensembl: ENSG00000139668

Variants:

dbSNP: 115825
ClinVar: 115825
TCGA: ENSG00000139668
COSMIC: WDFY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139668ENST00000298125Q96P53
ENSG00000139668ENST00000612477A0A087WZX3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
367801722023Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS†.1
367801722023Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS†.1
312538012019WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.20
317893422019P63 modulates the expression of the WDFY2 gene which is implicated in cancer regulation and limb development.4
312538012019WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.20
317893422019P63 modulates the expression of the WDFY2 gene which is implicated in cancer regulation and limb development.4
286539002017Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway.9
286539002017Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway.9
246756772014CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma.25
246756772014CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma.25
173136512007WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.13
173136512007WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.13
167925292006A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.19
168735532006The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.31
167925292006A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.19

Citation

Dessen P

WDFY2 (WD repeat and FYVE domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55005/wdfy2-(wd-repeat-and-fyve-domain-containing-2)