DBNL (drebrin like)

2015-02-01  

Identity

HGNC
DBNL
LOCATION
7p13
LOCUSID
28988
ALIAS
ABP1,HIP-55,HIP55,SH3P7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28988
MIM: 610106
HGNC: 2696
Ensembl: ENSG00000136279

Variants:

dbSNP: 28988
ClinVar: 28988
TCGA: ENSG00000136279
COSMIC: DBNL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136279ENST00000411855F8WBB2
ENSG00000136279ENST00000429716F8WFE1
ENSG00000136279ENST00000432854H0Y5J4
ENSG00000136279ENST00000439815F8WB73
ENSG00000136279ENST00000440166Q9UJU6
ENSG00000136279ENST00000441840F8WC20
ENSG00000136279ENST00000441904F2Z3E3
ENSG00000136279ENST00000448521Q9UJU6
ENSG00000136279ENST00000452661H7C111
ENSG00000136279ENST00000452943B4DDD6
ENSG00000136279ENST00000456905Q9UJU6
ENSG00000136279ENST00000458579F2Z2V3
ENSG00000136279ENST00000464762F8WBG8
ENSG00000136279ENST00000468694Q9UJU6
ENSG00000136279ENST00000485932F8WCK3
ENSG00000136279ENST00000490734Q9UJU6
ENSG00000136279ENST00000494774Q9UJU6
ENSG00000136279ENST00000498733F2Z3E3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188299612008The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation.41
147296632004Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.26
125658382003Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference.19
160557012005HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.18
145572762003The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.14
173062572007Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55.12
224508132012The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions.12
116890062001Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.9
249125702014Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.7
257151762015Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment of Psoriasis.7

Citation

Dessen P

DBNL (drebrin like)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55016/dbnl-(drebrin-like)