KNSTRN (kinetochore localized astrin (SPAG5) binding protein)

2015-02-01  

Identity

HGNC
KNSTRN
LOCATION
15q15.1
LOCUSID
90417
ALIAS
C15orf23,HSD11,ROCHIS,SKAP,TRAF4AF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90417
MIM: 614718
HGNC: 30767
Ensembl: ENSG00000128944

Variants:

dbSNP: 90417
ClinVar: 90417
TCGA: ENSG00000128944
COSMIC: KNSTRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128944ENST00000249776Q9Y448
ENSG00000128944ENST00000416151Q9Y448
ENSG00000128944ENST00000448395Q9Y448
ENSG00000128944ENST00000557920H0YM11
ENSG00000128944ENST00000559083H0YN50
ENSG00000128944ENST00000559304H0YKD4
ENSG00000128944ENST00000560220H0YNN6
ENSG00000128944ENST00000560321H0YLA7
ENSG00000128944ENST00000560981H0YLH8
ENSG00000128944ENST00000561169H0YKF8
ENSG00000128944ENST00000608100V9GY01

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345542412022SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation.2
352019672022Phosphorylation of small kinetochore-associated protein induced by GSK3β promotes cell migration and invasion in esophageal cancer.1
345542412022SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation.2
352019672022Phosphorylation of small kinetochore-associated protein induced by GSK3β promotes cell migration and invasion in esophageal cancer.1
334524592021KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer.22
335103462021Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle.0
334524592021KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer.22
335103462021Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle.0
309728802019Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.7
309728802019Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.7
287517102017Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.41
288411342017Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.25
287517102017Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.41
288411342017Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.25
264338802016Absence of KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation, in Other Solid Tumors and Leukemias.4

Citation

Dessen P

KNSTRN (kinetochore localized astrin (SPAG5) binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55018