Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
EP24.15,MEPD_HUMAN,MP78,TOP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7064
MIM: 601117
HGNC: 11793
Ensembl: ENSG00000172009
Variants:
dbSNP: 7064
ClinVar: 7064
TCGA: ENSG00000172009
COSMIC: THOP1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Renin-angiotensin system | KEGG | ko04614 |
| Renin-angiotensin system | KEGG | hsa04614 |
| African trypanosomiasis | KEGG | ko05143 |
| African trypanosomiasis | KEGG | hsa05143 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36997147 | 2023 | Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells. | 1 |
| 36997147 | 2023 | Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells. | 1 |
| 28148290 | 2017 | Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. | 16 |
| 28148290 | 2017 | Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. | 16 |
| 24604581 | 2014 | Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis. | 9 |
| 25180910 | 2014 | Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer. | 8 |
| 24604581 | 2014 | Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis. | 9 |
| 25180910 | 2014 | Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer. | 8 |
| 23708739 | 2013 | Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels. | 5 |
| 24223886 | 2013 | Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase. | 2 |
| 23708739 | 2013 | Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels. | 5 |
| 24223886 | 2013 | Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase. | 2 |
| 22796113 | 2012 | Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction. | 12 |
| 22796113 | 2012 | Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction. | 12 |
| 21151101 | 2011 | Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. | 52 |
Citation
Dessen P
THOP1 (thimet oligopeptidase 1)
Atlas Genet Cytogenet Oncol Haematol. 2015-02-01
Online version: http://atlasgeneticsoncology.org/gene/55021/thop1-(thimet-oligopeptidase-1)
