ESRP2 (epithelial splicing regulatory protein 2)

2015-02-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
RBM35B
FUSION GENES

Other Information

Locus ID:

NCBI: 80004
MIM: 612960
HGNC: 26152
Ensembl: ENSG00000103067

Variants:

dbSNP: 80004
ClinVar: 80004
TCGA: ENSG00000103067
COSMIC: ESRP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103067ENST00000473183Q9H6T0
ENSG00000103067ENST00000562724J3KRF2
ENSG00000103067ENST00000564382J3QQJ9
ENSG00000103067ENST00000565858Q9H6T0
ENSG00000103067ENST00000566774J3QKU3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379856442024Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression.3
379856442024Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression.3
345206222022The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.3
345206222022The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.3
319450162020Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.39
333395182020Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.9
333844392020Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.4
319450162020Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.39
333395182020Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.9
333844392020Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.4
314788292019Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer.35
314788292019Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer.35
303228072018Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.9
303228072018Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.9
274010762017Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.20

Citation

Dessen P

ESRP2 (epithelial splicing regulatory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55032/esrp2-(epithelial-splicing-regulatory-protein-2)