MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase)
2015-02-01 Affiliation
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10797
MIM: 604887
HGNC: 7434
Ensembl: ENSG00000065911
Variants:
dbSNP: 10797
ClinVar: 10797
TCGA: ENSG00000065911
COSMIC: MTHFD2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38287824 | 2024 | Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway. | 0 |
| 38422037 | 2024 | Implications of MTHFD2 expression in renal cell carcinoma aggressiveness. | 0 |
| 38723197 | 2024 | MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions. | 0 |
| 38287824 | 2024 | Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway. | 0 |
| 38422037 | 2024 | Implications of MTHFD2 expression in renal cell carcinoma aggressiveness. | 0 |
| 38723197 | 2024 | MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions. | 0 |
| 36493392 | 2023 | MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation. | 2 |
| 36601741 | 2023 | Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway. | 4 |
| 37484807 | 2023 | SNHG3/hsa-miR-455-5p Axis-mediated High Expression of MTHFD2 Correlates with Tumor Immune Infiltration and Endometrial Carcinoma Progression. | 0 |
| 36493392 | 2023 | MTHFD2 suppresses glioblastoma progression via the inhibition of ERK1/2 phosphorylation. | 2 |
| 36601741 | 2023 | Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway. | 4 |
| 37484807 | 2023 | SNHG3/hsa-miR-455-5p Axis-mediated High Expression of MTHFD2 Correlates with Tumor Immune Infiltration and Endometrial Carcinoma Progression. | 0 |
| 35135596 | 2022 | Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling. | 7 |
| 35228749 | 2022 | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. | 20 |
| 35349697 | 2022 | Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism. | 8 |
Citation
Dessen P
MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase)
Atlas Genet Cytogenet Oncol Haematol. 2015-02-01
