SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

2015-03-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
SSB-1,SSB1
FUSION GENES

Other Information

Locus ID:

NCBI: 80176
MIM: 611657
HGNC: 30628
Ensembl: ENSG00000171621

Variants:

dbSNP: 80176
ClinVar: 80176
TCGA: ENSG00000171621
COSMIC: SPSB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171621ENST00000328089Q96BD6
ENSG00000171621ENST00000328089A0A024R4G8
ENSG00000171621ENST00000357898Q96BD6
ENSG00000171621ENST00000357898A0A024R4G8
ENSG00000171621ENST00000377399Q96BD6
ENSG00000171621ENST00000377399A0A024R4G8
ENSG00000171621ENST00000450402A2A276

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
196835012009SOSS complexes participate in the maintenance of genomic stability.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
280843292017SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.17
260324132015SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.13
247862062014SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.12
307129442019SPSB1 enhances ovarian cancer cell survival by destabilizing p21.2

Citation

Dessen P

SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55096/spsb1-(spla-ryanodine-receptor-domain-and-socs-box-containing-1)