Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51660
MIM: 614738
HGNC: 21606
Ensembl: ENSG00000060762
Variants:
dbSNP: 51660
ClinVar: 51660
TCGA: ENSG00000060762
COSMIC: MPC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000060762 | ENST00000341756 | Q5TI65 |
| ENSG00000060762 | ENST00000360961 | Q9Y5U8 |
| ENSG00000060762 | ENST00000621630 | A0A087WVZ0 |
| ENSG00000060762 | ENST00000621685 | Q5TI65 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38354856 | 2024 | Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer. | 0 |
| 38354856 | 2024 | Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer. | 0 |
| 36651176 | 2023 | Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease. | 17 |
| 36708143 | 2023 | Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming. | 2 |
| 36651176 | 2023 | Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease. | 17 |
| 36708143 | 2023 | Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming. | 2 |
| 34873722 | 2022 | Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. | 6 |
| 34873722 | 2022 | Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. | 6 |
| 34664967 | 2021 | Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes. | 6 |
| 34664967 | 2021 | Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes. | 6 |
| 31641207 | 2020 | A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. | 31 |
| 32403431 | 2020 | Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases. | 12 |
| 32664896 | 2020 | Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy. | 4 |
| 32708919 | 2020 | The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. | 38 |
| 32851100 | 2020 | MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin. | 3 |
Citation
Dessen P
MPC1 (mitochondrial pyruvate carrier 1)
Atlas Genet Cytogenet Oncol Haematol. 2015-03-01
Online version: http://atlasgeneticsoncology.org/gene/55114/mpc1-(mitochondrial-pyruvate-carrier-1)
