NLRC3 (NLR family CARD domain containing 3)

2015-03-01  

Identity

HGNC
NLRC3
LOCATION
16p13.3
LOCUSID
197358
ALIAS
CLR16.2,NOD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 197358
MIM: 615648
HGNC: 29889
Ensembl: ENSG00000167984

Variants:

dbSNP: 197358
ClinVar: 197358
TCGA: ENSG00000167984
COSMIC: NLRC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167984ENST00000324659H3BLT9
ENSG00000167984ENST00000359128Q7RTR2
ENSG00000167984ENST00000359128C3VPR7
ENSG00000167984ENST00000615877Q7RTR2
ENSG00000167984ENST00000618137A0A087WZ24

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619

References

Pubmed IDYearTitleCitations
368081662023NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma.0
375864552023NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway.1
377088492023Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.0
368081662023NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma.0
375864552023NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway.1
377088492023Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.0
345331222021[Knockdown of NLRC3 promotes proliferation and invasion of human colon cancer cells].0
345331222021[Knockdown of NLRC3 promotes proliferation and invasion of human colon cancer cells].0
325845092020NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6/JAK2/STAT3 pathway activation.6
325845092020NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6/JAK2/STAT3 pathway activation.6
313036172019[Association of NLRC3 with prognosis and tumor immunity in patients with stage III colorectal cancer].1
313036172019[Association of NLRC3 with prognosis and tumor immunity in patients with stage III colorectal cancer].1
300811502018The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma.7
300811502018The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma.7
285840532017NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding.24

Citation

Dessen P

NLRC3 (NLR family CARD domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55120/nlrc3-(nlr-family-card-domain-containing-3)