SERPIND1 (serpin family D member 1)

2015-03-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
D22S673,HC2,HCF2,HCII,HLS2,LS2,THPH10

Other Information

Locus ID:

NCBI: 3053
MIM: 142360
HGNC: 4838
Ensembl: ENSG00000099937

Variants:

dbSNP: 3053
ClinVar: 3053
TCGA: ENSG00000099937
COSMIC: SERPIND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099937ENST00000215727P05546
ENSG00000099937ENST00000406799P05546

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362447452023Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus.1
362447452023Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus.1
328274482020Identification and characterization of a novel isoform of heparin cofactor II in human liver.2
328274482020Identification and characterization of a novel isoform of heparin cofactor II in human liver.2
280872792017Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.6
285029172017The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.7
280872792017Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.6
285029172017The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.7
274306602016Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.13
274306602016Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.13
251307702015Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.14
251307702015Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.14
234968732013The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.2
236567342013Proteolytic activation transforms heparin cofactor II into a host defense molecule.17
234968732013The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.2

Citation

Dessen P

SERPIND1 (serpin family D member 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55122/serpind1-(serpin-family-d-member-1)