GINS4 (GINS complex subunit 4)

2015-04-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
SLD5
FUSION GENES

Other Information

Locus ID:

NCBI: 84296
MIM: 610611
HGNC: 28226
Ensembl: ENSG00000147536

Variants:

dbSNP: 84296
ClinVar: 84296
TCGA: ENSG00000147536
COSMIC: GINS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147536ENST00000276533Q9BRT9
ENSG00000147536ENST00000518671Q9BRT9
ENSG00000147536ENST00000520354E5RH56
ENSG00000147536ENST00000520710Q9BRT9
ENSG00000147536ENST00000523277E5RFF9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362734552024MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.1
362734552024MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.1
366288102023Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis.3
375085492023The Molecular Pathogenesis of Tumor-Suppressive miR-486-5p and miR-486-3p Target Genes: GINS4 Facilitates Aggressiveness in Lung Adenocarcinoma.2
366288102023Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis.3
375085492023The Molecular Pathogenesis of Tumor-Suppressive miR-486-5p and miR-486-3p Target Genes: GINS4 Facilitates Aggressiveness in Lung Adenocarcinoma.2
353651752022GINS4 might be a novel prognostic immune-related biomarker of not only esophageal squamous cell carcinoma and other cancers.2
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
363459432022Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.6
353651752022GINS4 might be a novel prognostic immune-related biomarker of not only esophageal squamous cell carcinoma and other cancers.2
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
363459432022Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.6
345560222021Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients.8
348825342021Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle.0
345560222021Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients.8

Citation

Dessen P

GINS4 (GINS complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-04-01

Online version: http://atlasgeneticsoncology.org/gene/55151/gins4-(gins-complex-subunit-4)