Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9376
MIM: 607581
HGNC: 10972
Ensembl: ENSG00000149452
Variants:
dbSNP: 9376
ClinVar: 9376
TCGA: ENSG00000149452
COSMIC: SLC22A8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA448852 | cefotaxime | Chemical | ClinicalAnnotation | associated | PK | 23649425 | |
| PA450428 | methotrexate | Chemical | Pathway | associated | 21317831, 25502615 | ||
| PA451089 | pravastatin | Chemical | Pathway | associated | |||
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35406626 | 2022 | Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort. | 4 |
| 36316339 | 2022 | Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions. | 7 |
| 35406626 | 2022 | Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort. | 4 |
| 36316339 | 2022 | Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions. | 7 |
| 33836300 | 2021 | Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents. | 0 |
| 33836300 | 2021 | Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents. | 0 |
| 31691080 | 2020 | Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. | 4 |
| 31691080 | 2020 | Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. | 4 |
| 30653465 | 2019 | Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. | 9 |
| 30761470 | 2019 | Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3. | 17 |
| 31054272 | 2019 | The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. | 4 |
| 30653465 | 2019 | Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. | 9 |
| 30761470 | 2019 | Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3. | 17 |
| 31054272 | 2019 | The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. | 4 |
| 29285751 | 2018 | Endogenous Metabolites-Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity. | 8 |
Citation
Dessen P
SLC22A8 (solute carrier family 22 member 8)
Atlas Genet Cytogenet Oncol Haematol. 2015-04-01
Online version: http://atlasgeneticsoncology.org/gene/55174/slc22a8-(solute-carrier-family-22-member-8)
