Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 150
MIM: 104210
HGNC: 281
Ensembl: ENSG00000150594
Variants:
dbSNP: 150
ClinVar: 150
TCGA: ENSG00000150594
COSMIC: ADRA2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000150594 | ENST00000280155 | P08913 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | ClinicalAnnotation | associated | PD | 25642918 | |
| PA164752812 | milnacipran | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445208 | Pain | Disease | VariantAnnotation | not associated | PD | 21398039 | |
| PA445210 | Pain, Postoperative | Disease | ClinicalAnnotation | associated | PD | ||
| PA446479 | Hypertrophy, Left Ventricular | Disease | ClinicalAnnotation | associated | PD | 15614026 | |
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 17283289, 18200436, 19150055, 21103886, 23609393, 29230023 | |
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | ||
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 25642918 | |
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 15614026 | |
| PA448665 | brimonidine | Chemical | Pathway | associated | |||
| PA449051 | clonidine | Chemical | Pathway | associated | |||
| PA449256 | dexmedetomidine | Chemical | ClinicalAnnotation | associated | PD | 21104443 | |
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 17283289, 18200436, 19150055, 21103886, 23609393, 29230023 | |
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA451946 | yohimbine | Chemical | Pathway | associated | |||
| PA452618 | opioids | Chemical | VariantAnnotation | not associated | PD | 21398039 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 39028822 | 2024 | Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. | 0 |
| 39028822 | 2024 | Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. | 0 |
| 37029295 | 2023 | Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders. | 4 |
| 37310179 | 2023 | The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder. | 0 |
| 37828025 | 2023 | ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon. | 4 |
| 37029295 | 2023 | Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders. | 4 |
| 37310179 | 2023 | The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder. | 0 |
| 37828025 | 2023 | ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon. | 4 |
| 34965503 | 2022 | The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism. | 2 |
| 35429176 | 2022 | A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients. | 1 |
| 34965503 | 2022 | The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism. | 2 |
| 35429176 | 2022 | A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients. | 1 |
| 29482474 | 2021 | Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders. | 3 |
| 34182128 | 2021 | Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders. | 5 |
| 34237656 | 2021 | α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. | 5 |
Citation
Dessen P
ADRA2A (adrenoceptor alpha 2A)
Atlas Genet Cytogenet Oncol Haematol. 2015-05-01
Online version: http://atlasgeneticsoncology.org/gene/55181/adra2a-(adrenoceptor-alpha-2a)
