ADRA2A (adrenoceptor alpha 2A)

2015-05-01 Affiliation

Identity

HGNC

ADRA2A

LOCATION

10q25.2

LOCUSID

150

ALIAS

ADRA2,ADRA2R,ADRAR,ALPHA2AAR,ZNF32

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 150
MIM: 104210
HGNC: 281
Ensembl: ENSG00000150594

Variants:

dbSNP: 150
ClinVar: 150
TCGA: ENSG00000150594
COSMIC: ADRA2A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000150594	ENST00000280155	P08913

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Metabolism of proteins	REACTOME	R-HSA-392499
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptor	REACTOME	R-HSA-392023
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Surfactant metabolism	REACTOME	R-HSA-5683826

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated	PD	25642918
PA164752812	milnacipran	Chemical	ClinicalAnnotation	associated	PD
PA445208	Pain	Disease	VariantAnnotation	not associated	PD	21398039
PA445210	Pain, Postoperative	Disease	ClinicalAnnotation	associated	PD
PA446479	Hypertrophy, Left Ventricular	Disease	ClinicalAnnotation	associated	PD	15614026
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA447207	Depressive Disorder	Disease	ClinicalAnnotation	associated	PD
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	25642918
PA448499	atenolol	Chemical	ClinicalAnnotation	associated	PD	15614026
PA448665	brimonidine	Chemical	Pathway	associated
PA449051	clonidine	Chemical	Pathway	associated
PA449256	dexmedetomidine	Chemical	ClinicalAnnotation	associated	PD	21104443
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450464	methylphenidate	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PD	17283289, 18200436, 19150055, 21103886, 23609393, 29230023
PA450649	norepinephrine	Chemical	Pathway	associated
PA451946	yohimbine	Chemical	Pathway	associated
PA452618	opioids	Chemical	VariantAnnotation	not associated	PD	21398039

References

Pubmed ID	Year	Title	Citations
39028822	2024	Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.	0
39028822	2024	Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.	0
37029295	2023	Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.	4
37310179	2023	The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.	0
37828025	2023	ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.	4
37029295	2023	Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.	4
37310179	2023	The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.	0
37828025	2023	ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.	4
34965503	2022	The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.	2
35429176	2022	A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.	1
34965503	2022	The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.	2
35429176	2022	A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.	1
29482474	2021	Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders.	3
34182128	2021	Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.	5
34237656	2021	α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.	5

Citation

Dessen P

ADRA2A (adrenoceptor alpha 2A)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55181/js/cancer-prone-explorer/favicon/humanGenome