CCT2 (chaperonin containing TCP1 subunit 2)

2015-05-01  

Identity

HGNC
CCT2
LOCATION
12q15
LOCUSID
10576
ALIAS
99D8.1,CCT-beta,CCTB,HEL-S-100n,PRO1633,TCP-1-beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10576
MIM: 605139
HGNC: 1615
Ensembl: ENSG00000166226

Variants:

dbSNP: 10576
ClinVar: 10576
TCGA: ENSG00000166226
COSMIC: CCT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166226ENST00000299300P78371
ENSG00000166226ENST00000299300V9HW96
ENSG00000166226ENST00000543146P78371
ENSG00000166226ENST00000544368F5GWF6
ENSG00000166226ENST00000550010F8VQ14

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381655472024CCT2 prevented β-catenin proteasomal degradation to sustain cancer stem cell traits and promote tumor progression in epithelial ovarian cancer.0
381655472024CCT2 prevented β-catenin proteasomal degradation to sustain cancer stem cell traits and promote tumor progression in epithelial ovarian cancer.0
314627072020Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.25
319649052020Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis.28
314627072020Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.25
319649052020Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis.28
294836662018Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing.14
294836662018Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing.14
276457722016CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.17
276457722016CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.17
257047582015Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.65
257047582015Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.65
243754122014Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.19
243754122014Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.19
237824732013Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.18

Citation

Dessen P

CCT2 (chaperonin containing TCP1 subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55185/cct2-(chaperonin-containing-tcp1-subunit-2)