Identity
HGNC
LOCATION
16p13.12
LOCUSID
ALIAS
DAN,DKCB6,PFBMFT4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5073
MIM: 604212
HGNC: 8609
Ensembl: ENSG00000140694
Variants:
dbSNP: 5073
ClinVar: 5073
TCGA: ENSG00000140694
COSMIC: PARN
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31936572 | 2020 | Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN). | 3 |
| 32457045 | 2020 | Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation. | 5 |
| 31936572 | 2020 | Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN). | 3 |
| 32457045 | 2020 | Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation. | 5 |
| 30591540 | 2019 | Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs. | 16 |
| 30770239 | 2019 | The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. | 41 |
| 30930056 | 2019 | Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. | 35 |
| 31273937 | 2019 | Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. | 18 |
| 31387300 | 2019 | The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage. | 7 |
| 31448843 | 2019 | From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants. | 7 |
| 30591540 | 2019 | Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs. | 16 |
| 30770239 | 2019 | The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. | 41 |
| 30930056 | 2019 | Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. | 35 |
| 31273937 | 2019 | Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. | 18 |
| 31387300 | 2019 | The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage. | 7 |
Citation
Dessen P
PARN (poly(A)-specific ribonuclease)
Atlas Genet Cytogenet Oncol Haematol. 2015-05-01
Online version: http://atlasgeneticsoncology.org/gene/55216
