SEMA4B (semaphorin 4B)

2015-05-01  

Identity

HGNC
SEMA4B
LOCATION
15q26.1
LOCUSID
10509
ALIAS
SEMAC,SemC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10509
MIM: 617029
HGNC: 10730
Ensembl: ENSG00000185033

Variants:

dbSNP: 10509
ClinVar: 10509
TCGA: ENSG00000185033
COSMIC: SEMA4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185033ENST00000332496Q9NPR2
ENSG00000185033ENST00000411539Q9NPR2
ENSG00000185033ENST00000558895H0YMR1
ENSG00000185033ENST00000559074H0YMZ3
ENSG00000185033ENST00000559247H0YNM2
ENSG00000185033ENST00000559300H0YKV7
ENSG00000185033ENST00000559322H0YLN3
ENSG00000185033ENST00000559792H0YMD6
ENSG00000185033ENST00000559983H0YN49
ENSG00000185033ENST00000560089H0YM68
ENSG00000185033ENST00000561085H0YNC4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
356766882022Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma.5
361158542022CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.21
356766882022Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma.5
361158542022CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.21
257463852015SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo.28
257463852015SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo.28
244742522014Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion.9
250959812014SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer.25
244742522014Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion.9
250959812014SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer.25
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

SEMA4B (semaphorin 4B)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55219/sema4b-(semaphorin-4b)