Identity
HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
UNC84B,rab5IP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25777
MIM: 613569
HGNC: 14210
Ensembl: ENSG00000100242
Variants:
dbSNP: 25777
ClinVar: 25777
TCGA: ENSG00000100242
COSMIC: SUN2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell Cycle | REACTOME | R-HSA-1640170 |
| Meiosis | REACTOME | R-HSA-1500620 |
| Meiotic synapsis | REACTOME | R-HSA-1221632 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35435724 | 2022 | SUN2 Modulates the Propagation of HSV-1. | 1 |
| 35525855 | 2022 | FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. | 12 |
| 35435724 | 2022 | SUN2 Modulates the Propagation of HSV-1. | 1 |
| 35525855 | 2022 | FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. | 12 |
| 33648524 | 2021 | Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention. | 19 |
| 33686165 | 2021 | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | 9 |
| 33931868 | 2021 | Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1. | 4 |
| 33648524 | 2021 | Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention. | 19 |
| 33686165 | 2021 | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | 9 |
| 33931868 | 2021 | Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1. | 4 |
| 31935926 | 2020 | SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells. | 15 |
| 33058875 | 2020 | Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes. | 12 |
| 31935926 | 2020 | SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells. | 15 |
| 33058875 | 2020 | Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes. | 12 |
| 29408528 | 2018 | Structural conservation of the autoinhibitory domain in SUN proteins. | 11 |
Citation
Dessen P
SUN2 (Sad1 and UNC84 domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-05-01
Online version: http://atlasgeneticsoncology.org/gene/55222/
