XCL2 (X-C motif chemokine ligand 2)

2015-05-01  

Identity

HGNC
XCL2
LOCATION
1q24.2
LOCUSID
6846
ALIAS
SCM-1b,SCM1B,SCYC2

Other Information

Locus ID:

NCBI: 6846
MIM: 604828
HGNC: 10646
Ensembl: ENSG00000143185

Variants:

dbSNP: 6846
ClinVar: 6846
TCGA: ENSG00000143185
COSMIC: XCL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143185ENST00000367819Q9UBD3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365031632023Upregulated X-C motif chemokine ligand 2 (XCL2) is associated with poor prognosis and increased immune infiltration in clear cell renal cell carcinoma.2
367730492023The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis risk in the Han population.1
379059562023Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker.0
365031632023Upregulated X-C motif chemokine ligand 2 (XCL2) is associated with poor prognosis and increased immune infiltration in clear cell renal cell carcinoma.2
367730492023The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis risk in the Han population.1
379059562023Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker.0
271569462016Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.13
271569462016Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.13
254495362015Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.12
254977372015Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.37
254495362015Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.12
254977372015Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.37
250920912014Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.9
250920912014Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.9
186181752008Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages.4

Citation

Dessen P

XCL2 (X-C motif chemokine ligand 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55230/xcl2-(x-c-motif-chemokine-ligand-2)